Antioxidants are key to prostate cancer risk in some men

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A higher level of selenium, vitamin E and carotenoids lycopene tomatoes have shown that prostate cancer in men from four Caucasian, or those who say certain genetic changes are very sensitive to oxidative stress is inherited, reducing U.S. researchers.

has Conversely, if carriers of this genetic variant increased from low levels of vitamins and minerals, their risk for aggressive prostate significantly, as large as 10-fold, over those who maintain higher levels of nutrients, writes in today's edition of Cancer Research .


"This large prospective study provides further evidence that oxidative stress may be one of the most important mechanism for the development and progress of prostate cancer, and adequate intake of antioxidants such as selenium, lycopene and vitamin E may help prevent prostate cancer," said Dr. Li Haoji, a Researchers at Brigham and Women's Hospital and Harvard Medical School.

These new findings based on analysis of 567 men with prostate cancer between 1982 and 1995 and 764 cancer-free men were diagnosed with the Physicians Health Study is based.

The original aim of this study was to evaluate the effect of aspirin and beta-carotene to assess human health. Li's team decided to use a variant of the gene coding for manganese superoxide The dismutatase (MnSOD), an enzyme important as an antioxidant to check for defending against disease in human cells work.

MnSOD gene is transmitted from parents to offspring in one of three forms: VV, VA or AA.

"Compared with men with the MnSOD VV or VA genotype, those with AA genotype seem to be sensitive to antioxidant status," said Li. "Men with the AA genotype are more susceptible to prostate cancer if low antioxidant."

The results found that a quarter of men in the study of MnSOD AA genotype, half carried the VA genotype, and the remaining quarter carried VV genotype.

The results showed that VA and VV men were at risk of human resources equivalent to develop prostate cancer at all levels of antioxidants in the blood.

But compared to MnSOD VV or VA operator in the lowest quartile of selenium levels, MnSOD AA Do men 89 percent increased risk of aggressive prostate cancer if they have low blood levels of minerals.

On the other hand, MnSOD AA operators with high selenium - those in the highest quartile - had a 65 percent lower risk of MnSOD VV or VA males who receive small amounts of selenium.

"The level of selenium in the highest quartile of these people do not normally high," said Li. "Our jobs are not very high or very low."

While similar trends were observed Pls sources of lycopene and vitamin E were tested independently, the contrast in relative risk was mostly men who have expressed a high blood level to merge the three antioxidants, the researchers said.

"For men with the MnSOD AA genotype, we observed a 10-fold difference in risk of aggressive prostate cancer, Pls combined than men with high versus low levels of antioxidants," said Li. "In contrast, the genotype was in men with VV or VA, prostate cancer risk only slightly modified by the antioxidants."

"Our study, as well as many other epidemiological studies, intake of nutrients such as lycopene from tomato promote products or supplements for vitamin E and selenium reduces prostate cancer risk," said Li.

Prostate cancer is one of the biggest cancer killers in industrial countries and affects more than 500,000 people worldwide each year. This amount is expected to increase with the aging population.

Similar interactions between antioxidants and the variations in the MnSOD gene is associated with the previously issued to the risk of breast cancer.

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Posted in: Cancer,Prostate Cancer